Adsorption of rivanol onto nanocrystalline titania surface

Authors

  • O.V. Markitan Chuiko Institute of Surface Chemistry of National Academy of Sciences of Ukraine

DOI:

https://doi.org/10.15407/hftp16.03.414

Keywords:

titanium dioxide, rivanol, theory of surface complexation, Stern model, adsorption, isotherm, adsorption models

Abstract

Nanoscale oxide systems become the basis for research in the biotechnology field, medicine and environmental chemistry more frequently. Much attention is focused on titanium dioxide due to its low toxicity, stability of physicochemical parameters and high biocompatibility. It is known that titanium is a fairly inert material and has the ability to bind to bone tissue. It can be used for the manufacture of medical implants, the surface of which in the body is completely covered with a layer of its dioxide. This layer contacts and interacts with biological liquids directly, in which various biologically active substances may be present. In addition, understanding the nature of such interaction is very important issue, because it includes the formation of bonds of different nature between groups of biomolecules and surface functional groups of solids. Also, the issue of creation of potential carriers of biologically active substances that would be safe, biocompatible, stable and effective in the development of new therapeutic drugs is always relevant.

Diamino derivatives of acridine are widely used for the treatment of wounds, skin and mucous membranes in various types of infections due to the antimicrobial, antiviral and antibacterial properties. The aim of this work was be to study the adsorption of rivanol, which is one of the diamino derivatives of acridine, on the surface of nanocrystalline titanium dioxide and elucidate qualitative characteristics of such interaction.

The dependence of the stability constant of the surface complex TiO2-rivanol from the value of the ionic strength of the solution confirming the electrostatic nature of the interaction in the studied system was shoun based on the experimental dependences of rivanol adsorption on pH and ionic strength of the solution established by GRFIT program using Stern complexation models. According to the thermodynamic characteristics calculated on the basis of the effect of rivanol adsorption on its initial concentration in solution, the adsorption process is spontaneous for the studied system, has a favorable character on the surface of this sorbent and is carried out by the ion-exchange mechanism. The formation of a stable surface complex in the studied system indicates the prospects for using nanocrystalline titanium dioxide as a material for the creation of new therapeutic agents, where it can serve as a carrier of biologically active substances.

References

1. Subhan Md A., Neogi N., Choudhury K.P., Rahman M.M. Advances in biosensor applications of metal/metal-oxide nanoscale materials. Chemosensors. 2025. 13(2): 49. https://doi.org/10.3390/chemosensors13020049

2. Shahcheraghi N., Golchin H., Sadri Z., Tabari Y., Borhanifar F., Makani S. Nano biotechnology, an applicable approach for sustainable future. 3 Biotech. 2022. 12(3): 65. https://doi.org/10.1007/s13205-021-03108-9

3. Patra J.K., Das G., Fraceto L.F., Campos E.V.R., Rodriguez-Torres M. del P., Acosta-Torres L.S., Diaz-Torres L.A., Grillo R., Swamy M.K., Sharma S., Shin H.-S. Nano based drug delivery systems: recent developments and future prospects. J. Nanobiotech. 2018. 16(1): 71. https://doi.org/10.1186/s12951-018-0392-8

4. Shemetov A.A., Nabiev I., Sukhanova A. Molecular interaction of proteins and peptides with nanoparticles. ACS Nano. 2012. 6(6): 4585. https://doi.org/10.1021/nn300415x

5. Ai J., Biazar E., Jafarpour M., Montazeri M., Majdi A., Aminifard S., Zafari M., Akbari H.R., Hadi Gh Rad H.G. Nanotoxicology and nanoparticle safety in biomedical designs. Int. J. Nanomed. 2011. 6: 1117. https://doi.org/10.2147/IJN.S16603

6. Moghimi S.M., Hunter A.C., Murray J.C. Nanomedicine: current status and future prospects. FASEB J. 2005. 19(3): 311. https://doi.org/10.1096/fj.04-2747rev

7. Paunesku T., Rajh T. Biology of TiO2-oligonucleotide nanocomposites. Nat. Mater. 2003. 2(5): 343. https://doi.org/10.1038/nmat875

8. Fahrenkopf N.M., Rice P.Z., Bergkvist M., Deskins N.A., Cady N.C. Immobilization mechanism of deoxyribonucleic acid (DNA) to hafnium dioxide (HfO2) surface for biosensing applications. ACS. Appl. Mater. Interfaces. 2012. 4(10): 5360. https://doi.org/10.1021/am3013032

9. Stoch A., Jastrzebski W., Brozek A., Stoch J., Szaraniec J., Trybalska B., Kmita G. FTIR absorption-reflection study of biomimetic growth of phosphates on titanium implants. J. Mol. Struct. 2000. 555(1-3): 375. https://doi.org/10.1016/S0022-2860(00)00623-2

10. Engholm-Keller K., Larsen M.R. Titanium dioxide as chemoaffinity chromatographic sorbent of biomolecular compounds- applications in acidic modification-specific proteomics. J. Proteomics. 2011. 75(2): 317. https://doi.org/10.1016/j.jprot.2011.07.024

11. Lee J., Mahendra S., Alvarez P.J.J. Nanomaterials in construction industry:A review of their applications and environmental health and safety considerations. ACS Nano. 2010. 4(7): 3580. https://doi.org/10.1021/nn100866w

12. Moyano D.F., Rotello V.M. Nano meets biology. Structure and function of the nanoparticle interface. Langmuir. 2011. 27(17): 10276. https://doi.org/10.1021/la2004535

13. Fishre J., Egerton T.A. Titanium compounds. In: Inorganic kirk-othmer encyclopedia of chemical technology. (New York: Wiley-Interscience, 2001). https://doi.org/10.1002/0471238961.0914151805070518.a01.pub2

14. Gagner J.E., Shrivastava S., Qian X., Dordick J.S., Siegel R.W. Engineering nanomaterials for biomedical applications requires understanding the nano-bio interface: A perspective. J. Phys. Chem. Lett. 2012. 3(21): 3149. https://doi.org/10.1021/jz301253s

15. Stark W.J. Nanoparticles in bioilogical systems. Angew. Chem. Int. Ed. 2011. 50(6): 1242. https://doi.org/10.1002/anie.200906684

16. Jafari S., Mahyad B., Hashemzadeh H., Janfaza S., Gholikhani T., Tayebi L. Biomedical Applications of TiO2 Nanostructures: Recent Advances. Int. J. Nanomedicine. 2020. 15: 3447. https://doi.org/10.2147/IJN.S249441

17. Hashemzadeh H., Allahverdi A., Sedghi M., Vaezi Z., Tohidi Moghadam T., Rothbauer M., Fischer M.B., Ertl P., Naderi-Manesh H. PDMS nano-modified scaffolds for improvement of stem cells proliferation and differentiation in microfluidic platform. Nanomaterials. 2020. 10(4): 668. https://doi.org/10.3390/nano10040668

18. Molaeirad A., Janfaza S., Karimi-Fard A., Mahyad B. Photocurrent generation by adsorption of two main pigments of halobacterium salinarum on TiO2 nanostructured electrode. Biotechnol. Appl. Biochem. 2015. 62(1): 121. https://doi.org/10.1002/bab.1244

19. Wainwright M. Acridine-a neglected antibacterial chromophore. J. Antimicrob. Chemother. 2001. 47(1): 1. https://doi.org/10.1093/jac/47.1.1

20. Lerman L.S. Structural consideration of the interaction of DNA and acridines. J. Mol. Biol. 1961. 3(1): 18. https://doi.org/10.1016/S0022-2836(61)80004-1

21. Lenglet G., David-Cordonnier M.-H. DNA-destabilizing agents as an alternative approach for targeting DNA: Mechanisms of action and cellular consequences. J. Nucleic Acids. 2010. 2010: 1. https://doi.org/10.4061/2010/290935

22. Elderfield R. Heterocyclic compounds. V. 4. (New York: Publishing WILEY, 1952).

23. Albert A. Selective Toxicit: The physico-chemical basis of therapy. (London: Chapman&Hall, 1979).

24. Dawson R.M.C, Elliot D.C., Elliot W.H, Jones K.M. Data for Biochemical Research. (Oxford: Clarendon Press, 1986).

25. Haugen G.H., Melhuish W.H. Association and self-quenching of proflavine in water. Trans. Faraday Soc. 1964. 60(60): 386. https://doi.org/10.1039/tf9646000386

26. Schulman S.G., Naik D.V., Capomacchia A.C., Roy T. Electronic spectra and electronic structures of some antimicrobials derived from proflavine. J. Pharm. Sci. 1975. 64(6): 982. https://doi.org/10.1002/jps.2600640619

27. Vlasova N.M., Markitan O.V. Surface complexation modeling of biomolecule adsorptions onto titania. Colloids and Interfaces. 2019. 3(28): 1. https://doi.org/10.3390/colloids3010028

28. Westall J.C., Hohl H. A comparison of electrostatic models for the oxide/solution interface. Adv. Colloid Interface Sci. 1980. 12: 265. https://doi.org/10.1016/0001-8686(80)80012-1

29. Ludwig Chr. GRFIT, a program for solving speciation problems, evaluation of equilibrium constants, concentrations, and other physical parameters. (Internal Report of University of Bern, 1992).

30. Langmuir I. The constitution and fundamental properties of solids and liquids. J. Am. Chem. Soc. 1916. 38: 2221. https://doi.org/10.1021/ja02268a002

31. Tempkin M.I, Pyzhev V. Kinetics of ammonia synthesis on promoted iron catalyst. Acta Phys. Chim. USSR. 1940. 12: 327.

32. Dada A.O., Olalekan A.P., Olatunya A.M., Dada O. Langmuir, Freundlich, Temkin and Dubinin-Radushkevich isotherms studies of equilibrium sorption of Zn2+ unto phosphoric acid modified rice husk. J. Applied Chem. 2012. 3(1): 38. https://doi.org/10.9790/5736-0313845

33. Hall K.R., Eagleton L.C., Acrivos A., Vermeulen T. Pore and solid diffusion kinetics in fixed-bed adsorption under constant pattern conditions. Ind. Eng. Chem. Fundam. 1966. 5: 212. https://doi.org/10.1021/i160018a011

34. Freundlich H.M.F. ?ber die adsorption in l?sungen. Z. Phys. Chem. 1906. 57: 385. https://doi.org/10.1515/zpch-1907-5723

35. Ebabi A., Mohammadzadeh J.S.S., Khudiev A. What is correct form of BET isotherm for modeling liquid phase adsorption? Adsorption. 2009. 15: 65. https://doi.org/10.1007/s10450-009-9151-3

36. Dubinin M.M., Radushkevich L.V. On the equation of the characteristic curve for active coals. Proceedings of the USSR Academy of Sciences. 1947. 55: 331.

37. Redlich O., Peterson D.L. A useful adsorption isotherm. J. Phys. Chem. 1959. 63(6): 1024. https://doi.org/10.1021/j150576a611

Downloads

Published

28.08.2025

How to Cite

(1)
Markitan, O. Adsorption of Rivanol onto Nanocrystalline Titania Surface. Him. Fiz. Tehnol. Poverhni 2025, 16, 414-424.

Issue

Vol. 16 No. 3 (2025): Chemistry, Physics and Technology of Surface / Himia, Fizika ta Tehnologia Poverhni

Section

Articles

License

Copyright (c) 2025 O.V. Markitan

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

  1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
  2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.