Email the author Adding antibacterial/antiviral properties to medical purpose materials by modification with silver and copper nanoparticles
DOI: https://doi.org/10.15407/hftp16.01.063
Abstract
In modern times, especially during epidemics and pandemics, respiratory protection becomes especially important. One of the most effective means of protection against airborne infections such as influenza, SARS, and COVID-19 is 3-layer medical mask. The aim of this research is to modify medical purpose materials with Ag NPs and a mixture of Ag and Cu NPs to give their surface antibacterial/antiviral properties.
The study of the adsorption properties of medical purpose fabrics (using BET method for determining the specific surface area and distribution of pores by size depending on their radius in the tested fabric sample) has shown that their surface is characterized by the presence of micro-, meso-, and macropores, which is why, in addition to its high adsorption capacity for various substances, it can be used for modification with NPs using the method of adsorption from solutions. The nanoparticles are encapsulated by the porous structure of the tissue and retained in mesopores of 2–50 nm in size due to the action of capillary forces. To give the surface of medical purpose materials antibacterial/antiviral properties, a water-glycerol nanosuspension of Ag and a bicomponent water-glycerol nanosuspension of Ag and Cu were applied to their surface by the method of adsorption from solution. To modify the fabric, we used nanoparticles implanted physically (using ion-plasma technology in an environmentally friendly technological cycle, the ELIPS technology) into food glycerol and stabilized in it without the slightest additional chemical reagents. The initial suspension with Ag and Cu NPs and the structural transformations of immobilized nanoparticles on the tissue surface were studied by electron microscopy and micro-X-ray spectral analysis.
The results of a comprehensive study of the antiviral, antimicrobial, and antimycotic activity of Ag NPs and a mixture of Ag NPs and Cu has shown that bactericidal, fungicidal, and virucidal effects were observed at Ag NP concentration of 10 ppm. The composites of Ag and Cu NPs stabilized by silicon dioxide NPs were more active in inhibiting the growth of both Gram-negative and Gram-positive bacteria than those without the addition of silicon dioxide NPs.
Thus, NP-modified fabrics can be recommended for the manufacture of the middle layer of 3-layer medical masks, medical dressings, various underwear pads, baby nappies and diapers, bedding, medical uniforms, and other types of medical purpose products.
Keywords
References
1. Firdos Alam Khan. Materials for Medical Applications. Principles and Practices. (Oxon, RC Press Taylor and Francis group, LLS, 2024).
2. Normile P.S., De Toro J.A., Binns Ch. Effectiveness of Silver Nanoparticles Deposited in Facemask Material for Neutralizing Viruses. Nanomaterials. 2022. 12(15): 2662. https://doi.org/10.3390/nano12152662
3. Eremenko A.M., Petrik I.S., Rudenko A.V. Targeted requirements for biomedical nanomaterials based on dispersed oxides and textiles modified with metal NPS. Himia, Fizika ta Tehnologia Poverhni. 2023. 14(3): 300. https://doi.org/10.15407/hftp14.03.300
4. Rehan M., Mashaly H.M., Mowafi S., El-Kheir A.A., Emam H.E. Multi-functional textile design using in-situ Ag NPs incorporation into natural fabric matrix. Dyes Pigm. 2015. 118: 9. https://doi.org/10.1016/j.dyepig.2015.02.021
5. Liao M., Liu H., Wang X., Hu X., Huang Y., Liu X., Brenan K., Mecha J., Nirmalan M., Lu J.R. A technical review of face mask wearing in preventing respiratory COVID-19 transmission. Curr. Opin. Colloid Interface Sci. 2021. 52: 293. https://doi.org/10.1016/j.cocis.2021.101417
6. Kim J., Kwon S., Ostler E. Antimicrobial effect of silver-impregnated cellulose: potential for antimicrobial therapy. J. Biol. Eng. 2009. 3: 20. https://doi.org/10.1186/1754-1611-3-20
7. Andrusyshyna I.N. Metal nanoparticles: methods of obtaining, physicochemical properties, methods of research and toxicity assessment. Modern Problems of Toxicology. 2011. 3: 5. [in Russian].
8. Chekman I.S., Movchan B.A., Zahorodnyi M.I., Gaponov Y.V., Kurapov Y.A., Krushynskaya L.A., Kardash M.V. Nanosilver: Production technologies, pharmacological properties, indications for use. Preparaty i Technologii. 2008. 51(5): 32. [in Ukrainian].
9. Christian P., Kammer F., Baalousha M., Hofmann Th. Nanoparticles: structure, properties, preparation and behavior in environmental media. Ecotoxicology. 2008. 17: 326. https://doi.org/10.1007/s10646-008-0213-1
10. Ullah Khan S., Saleh T.A, Wahab A., Khan M.H.U., Khan D., Ullah Khan W., Rahim A., Kamal S., Ullah Khan F., Fahad S. Nanosilver: new ageless and versatile biomedical therapeutic scaffold. Int. J. Nanomedicine. 2018. 13: 733. https://doi.org/10.2147/IJN.S153167
11. Panacek A., Kvitek L., Prucek R., Kolar M., Vecerova R., Pizurova N., Sharma V.K., Nevecna T., Zboril R. Silver Colloid Nanoparticles: Synthesis, Characterization, and Their Antibacterial Activity. Phys. Chem. B. 2006. 110(33): 16248.
12. Marinescu L., Ficai D., Oprea O., Marin A., Ficai A., Andronescu E., Holban A.-M. Optimized Synthesis Approaches of Metal Nanoparticles with Antimicrobial Applications. J. Nanomater. 2020. 2020(4): 1. https://doi.org/10.1155/2020/6651207
13. Deshmukh S.P., Patil S.M., Mullani S.B., Delekar S.D. Silver nanoparticles as an effective disinfectant: A review. Mater. Sci. Eng. C. 2019. 97: 954. https://doi.org/10.1016/j.msec.2018.12.102
14. Chekman I.S., Mariyevskyi V.F., Rybalko S.L., Davtyan L.L., Dididkin G.G., Simonov P.V., Maletska Z.V. Antivirus activities of metal nanoparticles: a view of the problem. Ukrainian Medical Journal. 2015. 5(102): 45. [in Ukrainian].
15. Siddiqi K.S., Husen A., Rao R.A.K. A review on biosynthesis of silver nanoparticles and their biocidal properties. J. Nanobiotechnol. 2018. 16(1): 14. https://doi.org/10.1186/s12951-018-0334-5
16. Chwalibog A., Sawosz E., Hotowy A., Szeliga J., Mitura S., Mitura K., Grodzik M., Orlowski P., Sokolowska A. Visualization of interaction between inorganic nanoparticles and bacteria or fungi. Int. J. Nanomed. 2010. 5: 1085. https://doi.org/10.2147/IJN.S13532
17. Elechiguerra J.L., Burt J.L., Morones J.R., Camacho-Bragado A., Gao X., Lara H.H., Yacaman M.J. Interaction of silver nanoparticles with HIV-1. J. Nanobiotechnol. 2005. 3: 6. https://doi.org/10.1186/1477-3155-3-6
18. Kisterska L.D., Loginova O.B., Sadoknhin V.V., Sadokhin V.P. Innovative technology for the production of new generation biocompatible nanodisinfectants. Visnyk NAN Ukrainy. 2015. 1: 39. [in Ukrainian].
19. Kisterska L.D., Loginova O.B., Lysovenko S.O., Tkach V.M. Study of Silver and Copper Nanoparticles by Electron and Atomic Force Microscopy. Powder Metall. Met. Ceram. 2019. 58(5-6): 257. https://doi.org/10.1007/s11106-019-00076-x
20. Lv X., Wang P., Bai R., Cong Y., Suo S., Ren X., Chen Ch. Inhibitory effect of silver nanomaterials on transmissible virus-induced host cell infections. Biomaterials. 2014. 35(13): 4195. https://doi.org/10.1016/j.biomaterials.2014.01.054
21. Ruparelia J.P., Chatterjee A.K., Duttagupta S.P., Mukherji S. Strain specificity in antimicrobial activity of silver and copper nanoparticles. Acta Biomater. 2008. 4(3): 707. https://doi.org/10.1016/j.actbio.2007.11.006
22. Prado J.V. Vidal A.R., Duran N.C. Application of copper bactericidal properties in medical practice. Revista Medica de Chile. 2012. 140(10): 1325. https://doi.org/10.4067/S0034-98872012001000014
23. Kisterska L.D., Loginova O.B., Kondratiuk T.O., Beregova T.V., Boshytska N.V. Biostability of polyester fabric modified with nanodispersed silver suspension. Reports of the National Academy of Sciences of Ukraine. 2022. 1: 124. [in Ukrainian].
24. Sing K.S.W., Haul R.A.W., Moscou L., Pierotti R.A., Rouquerol J., Siemieniewska T. Reporting physisorption data for gas/solid systems with special reference to the determination of surface area and porosity (recommendations). Pure Appl. Chem. 1985. 57(4): 603. https://doi.org/10.1351/pac198557040603
25. Report of the L.V. Hromashevsky Institute of Epidemiology and Infectious Diseases of the National Academy of Medical Sciences of Ukraine. 2020. https://www.nanofluid.com.ua/ [in Ukrainian].
26. Kruyt H.R. Colloid science. V. 1. Irreversible systems. (Amsterdam, Elsevier Publishing, 1952).
27. Derygin B.V. The theory of stability of colloids and films. Surface forces. (Moscow: Nauka, 1986). [in Russian].
28. Yang R.T. Adsorbents: fundamentals and applications. (Hoboken, New Jersey: John Wiley & Sons, 2003).
29. Mendoza R., Oliva J., Rodriguez-Gonzalez V. Effect of the micro-, meso- and macropores on the electrochemical performance of supercapacitors. A review. Int. J. Energy Res. 2022. 6: 6989. https://doi.org/10.1002/er.7670
30. Diyuk V.E. Carbon sorbents. Obtaining, structure and properties. (Kyiv, VPC "Kyivskiy Universitet", 2017). [in Ukrainian].
DOI: https://doi.org/10.15407/hftp16.01.063
Copyright (©) 2025
This work is licensed under a Creative Commons Attribution 4.0 International License.