Chemistry, Physics and Technology of Surface

ISSN 2518-1238 (Online), ISSN 2079-1704 (Print)

The purpose of the review is to analyze and summarize the results of the works performed at Chuiko Institute of Surface Chemistry of NAS of Ukraine, dedicated to the synthesis and study of the properties of new magnetic fluids (MF) containing NC of superparamagnetic core – multilevel shell type and characterized by the functions of medico-biologic nanorobots. The research themes are focused on the creation of the latest medical theranostic remedies for targeted delivery and local complex treatment, primarily for needs of oncology.

The methodology of the work includes formulation of the problem of synthesis of NC of superparamagnetic core-multilevel shell type with the functions of biomedical nanorobots, relative MF, comprehensive studies of magnetic, structural and rheological characteristics, sedimentation stability, antitumor activity in vitro, in vivo.

It has been shown that calculations of the magnetization curve of MF based on single-domain superparamagnetic Fe₃O₄, within the framework of Langevin’s theory of paramagnetism, are satisfactorily coordinated with the experimental results, assuming that the saturation magnetization of magnetite particles depends on their size. On the basis of the obtained data, the idea has been formulated of using an ensemble of magnetic fluid nanoparticles as a superparamagnetic probe to diagnose its parameters and to substantiate the development of the magnetic granulometry method and the possibility of its application to measure the size parameters of a complex shell structure of magnetically sensitive nanocomposites of superparamagnetic core – multilevel shell type.

The obtained data develop the physicochemical basis for the development of new types of vector systems of anticancer drugs based on MF and have been used to improve the method of magnetic granulometry in order to optimize, standardize and control their parameters in the production process. In particular, the synthesized MF and the approaches to their magnetic diagnostics given in this work have been used in the creation of a new native oncological remedy “Feroplat” that has no analogues in the world, is a conjugate of nanoparticles of MF with cisplatin, is a standardized remedy for enhancement of the effectiveness of chemotherapy and overcoming of drug resistance of malignant neoplasms, designed to deliver cytostatic agent directly to the tumor tissue, ensuring maximal its entrance into cells and favoring an increase in the therapeutic effect. In order to be introduced into the production and clinical practice, feroplat is on a stage of completion of preclinical testing.

The data are given on the cytotoxic properties and biological safety of MF containing cisplatin. It has been shown that on the general and biochemical parameters of the blood, the use of MF does not make a more toxic influence on the body, compared with the antitumor drug cisplatin in equivalent doses.

The technological scheme is presented for manufacturing of a new magnetocarried polyfunctional antitumor vector system based on MF containing drugs in the structure of core-shell type nanocomposites.

The results of the work are used also in the development of new magnetocarried adsorption materials for technical, technological, ecological and biomedical purposes, in the educational process of native universities in training of bachelors and masters of the corresponding specialties.

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2. Shpak A.P., Gorbyk P.P. Nanomaterials and Supramolecular Structures: Physics, Chemistry, and Applications. (Netherlands: Springer, 2009). https://doi.org/10.1007/978-90-481-2309-4

3. Gorbyk P.P., Turov V.V. Nanomaterials and Nanocomposites in Medicine, Biology, Ecology. (Kyiv: Naukova dumka, 2011). [in Russian].

4. Patent UA 99211. Gorbyk P.P., Petranovska A.L., Turelyk M.P., Turanska S.P., Vasylieva O.A., Chekhun V.F., Lukyanova N.Yu., Shpak A.P., Korduban O.M. Nanocapsule with nanorobot functions. 2012.

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8. Gorbyk P.P., Lerman L.B., Petranovska A.L., Turanska S.P., Pylypchuk I.V. Magnetosensitive Nanocomposites with Hierarchical Nanoarchitecture as Biomedical Nanorobots: Synthesis, Properties, and Application. In: Fabrication and Self-Assembly of Nanobiomaterials, Applications of Nanobiomaterials. (Elsevier, 2016). https://doi.org/10.1016/B978-0-323-41533-0.00010-6

9. Pylypchuk I.V., Abramov M.V., Petranovska A.L., Turanska S.P., Budnyak T.M., Kusyak N.V., Gorbyk P.P. Multifunctional magnetic nanocomposites on the base of magnetite and hydroxyapatite for oncology applications. In: Nanochemistry, Biotechnology, Nanomaterials, and Their Applications: Selected Proceedings of the 5th International Conference of Nanotechnology and Nanomaterials (NANO 2017) (Aug. 23-26, 2017, Chernivtsi, Ukraine). P. 35. https://doi.org/10.1007/978-3-319-92567-7_2

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11. Fedorenko O.M., Gorbyk P.P., Chuiko O.O., Abramov M.V., Starokadomskyi D.L., Petranovska A.L. Ion-radical forms of oxygen adsorption on finely dispersed iron surface. Dopovidi NAN Ukrainy. 2004. 8: 161. [in Ukrainian].

12. Semko L.S., Storozhuk L.P., Gorbyk P.P., Kruchek Ye.I, Abramov N.V. Synthesis, Structure and Properties of Adsorbents Based on Magnetite and Transition Metals. In: Nanomaterials and Nanocomposites in Medicine, Biology, Ecology. (Kyiv: Naukova dumka, 2011). [in Russian].

13. Semko L.S., Kruchek Ye.I, Khutornoi S.V., Gorbyk P.P. Magnetocarried Gas-sensor Systems Based on Polymers, Nanocrystalline Nickel and Cobalt. In: Nanomaterials and Nanocomposites in Medicine, Biology, Ecology. (Kyiv: Naukova dumka, 2011). [in Russian].

14. Semko L.S., Kruchek O.I., Storozhuk L.P., Gorbyk P.P. Magnetocarried adsorbents based on nanocrystalline nickel. Metalofizyka i Novitni Tekhnolohii. 2011. 33(7): 985. [in Ukrainian].

15. Semko L.S., Kruchek O.I., Shevliakov Yu.A., Gorbyk P.P. Synthesis, structure, electrical and sensor properties of compositional materials based on polymers and nanocrystalline nickel. Fizyka i Khimiia Tverdoho Tila. 2009. 10(2): 447. [in Ukrainian].

16. Semko L.S., Gorbyk P.P., Shevliakov Yu.A., Chuiko O.O. Gas-sensor nanocomposites based on polyethylene and nanocrystalline nickel. Metalofizyka i Novitni Tekhnolohii. 2006. 28(6): 1001. [in Ukrainian].

17. Gorbyk P.P., Makhno S.M., Dubrovin I.V., Abramov M.V., Mishchenko V.M., Mazurenko R.V., Petranovska A.L., Pylypchuk Ye.V., Prokopenko S.L. Synthesis and properties of nanostructures absorbing ultrahigh frequency electromagnetic and neutron radiation. Nanosystemy, Nanomaterialy, Nanotekhnolohii. 2017. 15(1): 47. [in Ukrainian]. https://doi.org/10.15407/nnn.15.01.0047

18. Gorbyk P.P., Abramov M.V., Dubrovin I.V., Makhno S.M., Turanska S.P. Synthesis and properties of nanosized single-domain ferrites-spinels. Uspekhy Fyzyky Metallov. 2017. 18(1): 59. [in Ukrainian]. https://doi.org/10.15407/ufm.18.01.059

19. Gorbyk P.P., Mishchenko V.N., Abramov N.V., Troshchenkov Yu.N., Usov D.G. Magnetic properties of Fe3O4 nanoparticles obtained by chemical condensation method and solid-phase synthesis. Surface. 2010. 1(16): 165. [in Russian].

20. Gorbyk P.P., Dubrovin I.V., Abramov M.V. Synthesis, structure and magnetic characteristics of single-domain nanoparticles in solid solutions (Fe1-xMnx)Fe2O4. Surface. 2015. 7(22): 186. [in Ukrainian].

21. Gorbyk P.P., Dubrovin I.V., Abramov M.V. Synthesis, structure and magnetic characteristics of single-domain nanoparticles in solid solutions (Fe1-xNix)Fe2O4. Him. Fiz. Tehnol. Poverhn. 2017. 8(2): 194. [in Ukrainian]. https://doi.org/10.15407/hftp08.02.194

22. Gorbyk P.P., Dubrovin I.V., Abramov M.V. Synthesis, structure and magnetic characteristics of single-domain nanoparticles in solid solutions (Fe1-xCox)Fe2O4. Surface. 2012. 4(19): 232. [in Ukrainian].

23. Gorbyk P.P., Petranovska A.L., Pylypchuk Ye.V., Abramov N.V., Oranska Ye.I, Korduban A.M. Synthesis of magnetosensitive Gd-containing nanostructures. Him. Fiz. Tehnol. Poverhn. 2011. 2(4): 385. [in Russian].

24. Gorbyk P.P., Dubrovin I.V., Abramov M.V. Synthesis of single-domain crystalline particles of solid solutions (Fe1-xZnx) Fe2O4 and investigation of their magnetic characteristics. Him. Fiz. Tehnol. Poverhn. 2016. 7(2): 133. [in Ukrainian]. https://doi.org/10.15407/hftp07.02.133

25. Uvarova I.V., Gorbyk P.P., Gorobets S.V., Ivashchenko O.A., Ulianchenko N.V. Nanomaterials of Medical Destination. (Kyiv: Naukova dumka, 2014). [in Ukrainian].

26. Gorobets S.V., Gorobets O.Yu., Gorbyk P.P., Uvarova I.V. Functional Bio- and Nanomaterials of Medical Destination. (Kyiv: Kondor, 2018). [in Ukrainian].

27. Petranovska A.L., Abramov M.V., Opanashchuk N.M., Turanska S.P., Kusyak N.V., Gorbyk P.P. Synthesis and properties of magnetically sensitive nanocomposites based on magnetite and gemcitabine. Him. Fiz. Tehnol. Poverhn. 2018. 9(4): 353.

28. Petranovska A.L., Abramov M.V., Opanashchuk N.M., Turanska S.P., Gorbyk P.P., Kusyak N.V., Kusyak A.P., Lukyanova N.Yu., Chekhun V.F. Magnetically sensitive nanocomposites and magnetic liquids based on magnetite, gemcitabine, and antibody Her2. Him. Fiz. Tehnol. Poverhn. 2019. 10(4): 419.

29. Gorbyk P.P., Petranovska A.L., Turelyk M.P., Abramov N.V., Chekhun V.F., Lukyanova N.Yu. Construction of magnetocarried nanocomposites for medico-biological applications. Him. Fiz. Tehnol. Poverhn. 2010. 1(3): 360.

30. Gorbyk P.P., Dubrovin Y.V., Petranovska A.L., Turelyk M.P., Storozhuk L.P., Mishchenko V.N., Abramov N.V., Turanska S.P., Makhno S.N., Pylypchuk Ye.V., Chekhun V.F., Lukyanova N.Yu., Shpak A.P., Korduban A.M. Magnetocarried transport of medical preparations: contemporary state of development and prospects. Surface. 2010. 2(17): 287. [in Russian].

31. Turanska S.P., Kusyak A.P., Petranovska A.L., Gorobets S.V., Turov V.V., Gorbyk P.P. Cytotoxic activity of magnetocarried nanocomposites based on doxorubicin with example of Saccharomyces cerevisiae cells Him. Fiz. Tehnol. Poverhn. 2016. 7(2): 236. [in Ukrainian]. https://doi.org/10.15407/hftp07.02.236

32. Pylypchuk I.V., Kołodyńska D., Kozioł M., Gorbyk P.P. Gd-DTPA adsorption on chitosan/magnetite nanocomposites. Nanoscale Res. Lett. 2016. 11(1): 168. https://doi.org/10.1186/s11671-016-1363-3

33. Petranovska A.L., Abramov N.V., Turanska S.P., Gorbyk P.P., Kaminskiy A.N., Kusyak N.V. Adsorption of cis-dichlorodiammineplatinum by nanostructures based on single-domain magnetite. J. Nanostruct. Chem. 2015. 5(3): 275. https://doi.org/10.1007/s40097-015-0159-9

34. Abramov N.V., Turanska S.P., Kusyak A.P. Petranovska A.L., Gorbyk P.P. Synthesis and properties of magnetite/hydroxyapatite/doxorubicin nanocomposites and magnetic liquids based on them. J. Nanostruct. Chem. 2016. 6(3): 223. https://doi.org/10.1007/s40097-016-0196-z

35. Pylypchuk I.V., Kolodynska D., Gorbyk P.P. Gd(III) adsorption on the DTPA-functionalized chitosan/magnetite nanocomposites. Sep. Sci. Technol. 2018. 53(7): 1006. https://doi.org/10.1080/01496395.2017.1330830

36. Abramov M.V., Kusyak A.P., Kaminskyi O.M., Turanska S.P., Petranovska A.L., Kusyak N.V., Turov V.V., Gorbyk P.P. Synthesis and properties of magnetosensitive polyfunctional nanocomposites for application in oncology. Surface. 2017. 9(24): 165. [in Ukrainian]. https://doi.org/10.15407/Surface.2017.09.165

37. Gorbyk P.P., Kusyak N.V., Petranovska A.L., Oranska O.I., Abramov M.V., Opanashchuk N.M. Synthesis and properties of magnetosensitive nanostructures with carbonized surface. Him. Fiz. Tehnol. Poverhn. 2018. 9(2): 176. [in Ukrainian]. https://doi.org/10.15407/hftp09.02.176

38. Abramov M.V., Petranovska A.L., Pylypchuk Ye.V., Turanska S.P., Opanashchuk N.M., Kusyak N.V., Gorobets S.V., Gorbyk P.P. Magnetosensitive polyfunctional nanocomposites based on magnetite and hydroxyapatite for application in oncology. Surface. 2018. 10(25): 245. [in Ukrainian]. https://doi.org/10.15407/Surface.2018.10.245

39. Gorbyk P.P., Pylypchuk Ie.V., Petrenko V.I., Nikolaienko T.Yu. Synthesis and characterization of hybrid chitosan/magnetite nanocomposite fluid. J. Nano- Electron. Phys. 2019. 11(4): 04017. https://doi.org/10.21272/jnep.11(4).04017

40. Turanska S.P., Opanashchuk N.M., Petranovska A.L., Kusyak N.V., Tarasiuk B.I., Gorobets S.V., Turov V.V., Gorbyk P.P., Abramov M.V. Synthesis, properties and application in oncotherapy of nanocomposites based on gemcitabine. Surface. 2019. 11(26): 577. [in Ukrainian]. https://doi.org/10.15407/Surface.2019.11.577

41. Petranovska A.L., Pylypchuk Ie.V., Gorbyk P.P., Korduban O.M. Immobilization of ortho-thiocarborane onto nanocomposites of magnetite, doped with gadolinium oxide. Him. Fiz. Tehnol. Poverhn. 2017. 8(2): 203. [in Ukrainian]. https://doi.org/10.15407/hftp08.02.203

42. Patent UA 112490. Chekhun V.F., Lukyanova N.Yu., Gorbyk P.P., Todor I.M., Petranovska A.L., Boshytska N.V., Bozhko I.V. Antitumor ferromagnetic nanocomposite. 2016.

43. Pylypchuk Ye.V., Gorbyk P.P. V- and Gd-containing nanomaterials and nanocomposites for neutron capture therapy. Surface. 2014. 6(21): 150. [in Ukrainian].

44. Pylypchuk Ye.V., Zubchuk Yu.O., Petranovska A.L., Turanska S.P., Gorbyk P.P. Synthesis and properties of nanocomposites Fe3O4/hydroxyapatite/pamidronic acid/ diethylenetriaminepentaacetic acid/Gd3+. Him. Fiz. Tehnol. Poverhn. 2015. 6(3): 326. [in Ukrainian]. https://doi.org/10.15407/hftp06.03.326

45. Kusyak A.P., Petranovska A.L., Gorbyk P.P. Adsorption of Pb2+ cations from blood plasma by nanocomposites based on magnetite. Surface. 2016. 8(23): 179. [in Ukrainian]. https://doi.org/10.15407/Surface.2016.08.179

46. Semko L.S., Storozhuk L.P., Khutornoi S.V., Abramov N.V., Gorbyk P.P. Template synthesis, structure and properties of magnetocarried adsorbents magnetite/titanium dioxide with developed outer surface. Neorhanicheskiye materialy. 2015. 51(4): 1. [in Russian]. https://doi.org/10.1134/S0020168515040135

47. Kusyak A.P., Turanska S.P., Petranovska A.L., Gorbyk P.P. Adsorption of Zn2+, Cd2+ and Pb2+ cations by nanocomposites based on single-domain magnetite. Dopovidi NAN Ukrainy. 2015. 12: 90. [in Ukrainian]. https://doi.org/10.15407/dopovidi2015.12.090

48. Abramov M.V., Turanska S.P., Gorbyk P.P. Magnetic properties of nanocomposites of superparamagnetic core-shell type. Metalofizyka i Novitni Tekhnolohii. 2018. 40(4): 423. [in Ukrainian]. https://doi.org/10.15407/mfint.40.04.0423

49. Abramov M.V., Turanska S.P., Gorbyk P.P. Magnetic properties of fluids based on polyfunctional nanocomposites of superparamagnetic core-multilevel shell type. Metalofizyka i Novitni Tekhnolohii. 2018. 40(10): 1283. [in Ukrainian]. https://doi.org/10.15407/mfint.40.10.1283

50. Certificate 46056 TTR 03291669.012:2012 (temporary technological regulation for production of substance "Magnetite-U") / Gorbyk P.P., Abramov M.V., Petranovska A.L., Turelyk M.P., Vasylieva O.A. 2012. [in Ukrainian].

51. Certificate 58159 TTR 03291669.017:2014 (technological regulation for production of magnetic fluid) / Gorbyk P.P., Abramov M.V., Petranovska A.L., Pylypchuk Ye.V., Vasylieva O.A. 2015. [in Ukrainian].

52. Gorbyk P.P., Gorobets S.V., Turelyk M.P., Chekhun V.F., Shpak A.P. Biofunctionalization of Nanomaterials and Nanocomposites. (Kyiv: Naukova dumka, 2011). [in Ukrainian].

53. Gorbyk P.P. Magnetosensitive Nanocomposites with Nanorobot Functions: Synthesis, Properties, Application. In: Physics and Chemistry of Surface. (Kyiv: Interservis, 2018). [in Russian].