Adsorption of doxorubicin by fumed silica and magnetite/siloxane nanocomposites
Abstract
A technique has been developed for immobilization of the cytostatic drug doxorubicin on the surface of magnetite nanoparticles modified with biocompatible siloxane coating and fumed silica. The processes of adsorption/desorption of doxorubicin at given surfaces were studied, high adsorption activity of siloxane surface of nanocomposites was determined with respect to doxorubicin. New nanocomposites magnetite/siloxane/doxorubicin synthesized may be promising for use in oncology, in creating the remedies for targeted delivery of drugs and as adsorption materials for intracorporal and extracorporal detoxification of the organism.References
1. Gorbyk P., Turov V. Nanomaterials and nanocomposites in medicine, biology, ecology. (Kyiv: Naukova Dumka, 2011).
2. Roco M., Williams R., Alivisatos P. Nanotechnology research directions. Vision for Nanotechnology R&D in the Next Decade. (Dordrecht: Kluw. Acad. Publ, 2002). P. 171.
3. Mirzabeckov A.D. Biochips in Biology and Medicine of the XXI century. Bulletin of Medical Sciences. 2003. 73(5): 412. [In Russian].
4. Berezov T.T., Yaglov N.V., Dmitrieva T.B., Zhirkov Yu.A., Chekhonin V.P. Directed transport drugs via liposomes. Bulletin of Medical Sciences. 2004. 3: 42. [In Russian].
5. Nawara K., Romiszewski J., Kijewska K., Szczytko J., Twardowski A., Mazur M., Krysinski P. Adsorption of Doxorubicin onto Citrate-Stabilized Magnetic Nanoparticles. J. Phys. Chem. C. 2012. 116: 5598.
6. Sadighian S., Rostamizadeh K., Hosseini-Monfared H., Hamidi M. Doxorubicin-conjugated core-shell magnetite nanoparticles as dual-targeting carriers for anticancer drug delivery. Colloid. Surf. B. 2014. 117: 406.
7. Jinlou Gu, Gu J., Su S., Zhu M., Li Y., Zhao W., Duan Y., Shi J. Targeted doxorubicin delivery to liver cancer cells by PEGylated mesoporous silica nanoparticles with a pH-dependent release profile. Microporous Mesoporous Mater. 2012. 161: 160.
8. Sivak L.A., Eagle V.I., Klimanov M.U., Lyalkin S.A., Askolsky A.V. Features integrated methods of treating cancer patients using native device «Mahniterm». Clinical Oncology. 2011. Special Iss. I–II: 192.
9. Leary S., Liu C., Apuzzo M. Toward the emergence of nanoneurosurgery. Part II. Nanomedicine: diagnostics and imaging at the nanoscale level. Neurosurgery. 2006. 58: 805.
10. Hofmann A., Wenzel D., Becher U.M., Freitag D.F., Klein A.M., Eberbeck D., Schulte M., Zimmermann K., Bergemann C., Gleich B., Roell W., Weyh T., Trahms L., Nickenig G., Fleischmann B.K., Pfeifer A. Combined targeting of lentiviral vectors and positioning of transduced cells by magnetic nanoparticle. PNAS. 2009. 106: 44.
11. Nikolaev V., Sakhno L. Features modern sorption therapy in oncology. Clinical Oncology. 2011. Special Iss. II: 220.
12. Snezhkov E.A., Nikolaev V.G., Tridon A., Sarnatsky V.V., Jusko L.A. On the feasibility of establishing a heparin containing hemosorbents. Efferent Physical and Chemical Medicine. 2011. 2: 3.
13. Prokopowicz M. In-vitro controlled release of doxorubicin from silica xerogels. J. Pharmacy and Pharmacology. 2007. 59(10): 1365.
14. Nikolaev V. Enterosgel. (Kyiv: Bogdana, 2010).
15. Pre-clinical study of enterosorbents. Regulatory Document of Ministry of Health of Ukraine. 2010.
16. Lisichkin G.V. (ed.) Modified silicas in sorption, catalysis, and chromatography. (Moscow: Khimiya, 1986). [In Russian].
17. Gorbyk P.P., Abramov M.B., Penranovska A.L., Turelyk M.P., Vasilieva O.A Temporary technology reglament for production of Magnetit. U TTP 03291669.012:2012 matter: Sertificate of authors’ rule. N 46056.
18. Semko L.S., Gorbyk P.P., Storozhuk L.P., Dzyubenko L.S., Dubrovin I.V., Oransʹka O.I. Modification silica magnetite. Physics and Chemistry of Solid State. 2007. 8(3): 526.
19. Kovalenko A.S., Grin’ S.V., Il’in V.G. Characteristics of the Template Synthesis of Mesoporous Materials Based on Titanosilicon Esters. Teor. Exp. Chem. 2004. 40(1): 52.
20. Nakamoto K. IR Spectra of Inorganic and Coordination Compounds. (Moscow: Mir, 1991).
21. Little L. Infrared spectra of adsorbed molecules (Moscow: Mir, 1969).
22. Hergt R., Hiergeist R., Hilger I., Kaiser W.A., Lapatnikov Y., Margel S., Richter U. Magnetite nanoparticles with very high AC-losses for application in Rfmagnetic hyperthermia. J. Magn. Magn. Mater. 2004. 270: 345.
23. Carpenter E.E. Iron nanoparticles as potential magnetic carriers. J. Magn. Magn. Mater. 2001. 225: 20.
24. Chuiko A.A. (ed.) Surface chemistry of silica (Kyiv, 2001).
25. Chuiko A.A. (ed.) Medical chemistry and clinical use of silica (Kyiv: Naukova Dumka, 2003).
26. Tertykh V. Belyakova L. Chemical reactions involing silica surface. (Kyiv: Naukova Dumka, 1991).
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.
