Написати автору Структурна характеристика та біоактивність (in vitro) синтезованого золь-гель скла 60S, легованого Cu
DOI: https://doi.org/10.15407/hftp16.01.104
Анотація
Великий інтерес до різних типів біоактивного скла (BG) пояснюється високою біоактивністю, ангіогенними, остеогенними властивостями. У зв’язку з цим розробка металолегованого BG як матеріал для регенерації кісткової тканини привертає увагу наукової спільноти. З цієї мотивації дане дослідження зосереджено на дослідженні структури та біоактивності в умовах in vitro легованого міддю біоактивного скла 60S.
У даному дослідженні золь-гель методом синтезовано наноструктуровані зразки скла 60S зі складом (мол. %) 60 % SiO2, 36 – x % CaO, 4 % P2O5, легованого Cu (x = 0.25, 0.5 мол. %). Біологічну активність синтезованого матеріалу оцінювали методом in vitro. Динаміка утворення гідроксиапатиту (ГА), що сприяє формуванню ефективних зв’язків з кістками та м’якими тканинами під час занурення в симульовану рідину організму (SBF Kokubo), була оцінена за допомогою FTIR, XRD, SEM-EDX та ICP-AES.
Було виявлено, що збільшення вмісту легуючого елемента (зразок з 0.5 мол. % Cu) підвищує схильність BG до гідролізу, що проявляється в вищій активності іонообмінних процесів за участі іонних компонентів SBF. Крім того, утворення слабкокристалічного НА та фази кальциту при контакті з SBF характерно для обох зразків, що підтверджує біоактивність синтезованих зразків в умовах in vitro. Представлені результати є необхідними для подальших розробок та досліджень BG легованих Cu як перспективного матеріалу з остеопродуктивними, остеокондуктивними та антибактеріальними властивостями для тканинної регенерації та тканинної інженерії.
Ключові слова
Посилання
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DOI: https://doi.org/10.15407/hftp16.01.104
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