Написати автору Синтез та характеризація нанорозмірного люмінесцентного гідроксиапатиту, допованого тербієм
DOI: https://doi.org/10.15407/hftp16.01.115
Анотація
Метою роботи є синтез нового наноструктурованого біосумісного матеріалу з високою здатністю до рентгеноіндукованої люмінесценції. Було синтезувано допований тербієм гідроксиапатит, відомий своєю біосумісністю та нетоксичністю, двома способами: 1) осадженням іонів Ca2+ та Tb3+ розчином (NH4)2HPO4 у присутності різних біосумісних модифікаторів (CTAB, PEG-2000, тринатрію цитрату дигідрат); 2) катіонним заміщенням гідроксиапатиту в присутності тих самих модифікаторів при рН 4 і рН 6. Стехіометричне співвідношення (Ca+Tb)/P у вихідних розчинах підтримували на рівні біологічного гідроксиапатиту).
В результаті досліджень DLS, ELS та аналізу рентгеноіндукованої люмінесценції було встановлено, що найкращі ключові властивості, такі як ζ-потенціал і рентгеноіндукована люмінесценція, має зразок допованого 5 % (мол.) гідроксиапатиту, синтезованого методом співосадження в присутності тринатрію цитрату дигідрату. В результаті подальших досліджень методами TEM, FTIR, FT-NIR, TG/DTG/DTA, XRD, низькотемпературної адсорбції-десорбції азоту та ICP-AES було встановлено, що зразок має модифіковану цитратними групами поверхню, що зумовлює його високу колоїдну стабільність та може надавати високий адсорбційний потенціал. Значення співвідношення (Ca+Tb)/P становить 2.21 (мас.), що є близьким до значення біологічного гідроксиапатиту. Нанокомпозит характеризується високою рентгеноіндукованою люмінесценцією і може бути перспективним для адсорбційної іммобілізації біологічно активних сполук.
Результати дослідження свідчать про те, що знайдено оптимальні умови синтезу нанолюмінофорів, які є потенційними кандидатами для біомедичного застосування, враховуючи люмінесцентні властивості, низьку токсичність та можливість подальшої функціоналізації поверхні для адсорбційного насичення молекулами, що становлять медичний інтерес.
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DOI: https://doi.org/10.15407/hftp16.01.115
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