Chemistry, Physics and Technology of Surface

ISSN 2518-1238 (Online), ISSN 2079-1704 (Print)

Nowadays one of the perspective trends in manufacturing technology of prolonged release surgical materials  is introduction of bioactive substances into the polymer matrix. Earlier we synthesized the nanocomposite material "Polydens", which is an interpenetrating polymer network of polyurethane and poly(2-hydroxyethyl methacrylate) filled with silica modified by antimicrobial substances, namely metronidazole, decametoxin and silver nitrate. In this work we examined medical and biological properties of the synthesized material. The release kinetics of antimicrobial substances into the aqueous medium was studied by absorption spectrophotometry and chemical methods. The influence on the vital activity of yeast cells, antimicrobial properties, general toxic effect and reaction of the surrounding tissues of "Polydens" were investigated microscopically, by agar diffusion method and after subcutaneous implantation of material "Polydens" to test animals, respectively. It has been found that the nanocomposite is non-toxic, causes no severe local inflammatory reaction, and the release kinetics of bioactive substances does not inferior to the standard samples. Research of antimicrobial properties has shown that considered material significantly suppresses the vital activity of yeast cells and is characterized by a prolonged antibacterial effect. Polymer-based nanocomposite "Polydens" is a promising material in manufacturing of different medical devices, such as implants, catheters, drainages etc.

nanosilica; polyurethane; poly(2-hydroxyethyl methacrylate); silver nitrate; metronidazole; decamethoxin; yeast; release kinetics; antimicrobial action; implantation; toxicity

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