Chemistry, Physics and Technology of Surface

ISSN 2518-1238 (Online), ISSN 2079-1704 (Print)

Modern medicine (dentistry, orthopedics, traumatology) requires the creation of new composite materials, similar in structure, chemical composition and properties to natural tissue. It is necessary that the composition and structure of the composite maximally correspond to natural bone tissue, to improve characteristics such as bioactivity and biocompatibility. A promising direction is the application of composite materials based on hydroxyapatite (HAP) and biopolymers, in particular, proteins and carbohydrates (hyaluronic acid). The studies of a composite bioresorption in vitro using the dissolving HAP samples in both hydrochloric acid buffer and isotonic solution showed that the increased solubility of nanostructured HAP powders allows predicting their high bioactivity. One of the ways to regulate size of HAP particles in a biopolymer matrix can be to hold it in an acidic solution (pH ~ 5). The aim of this work is to study the processes of the influence of an acidic medium (hydrochloric acid solution) on the size of HAP crystals and the possibility of its aggregation with the formation of complex nano-structured agglomerates. Hydroxyapatite was obtained due to "wet" synthesis. A composite based on hydroxyapatite and hyaluronic acid (HAP / HA) was created using impregnating a synthesized HAP powder by a biopolymer solution. The process of acidic medium influence (hydrochloric acid solution) on hydroxyapatite (HAP) crystals size and the possibility of its aggregation with formation of complex nanoagglomerates were investigated using low-temperature ¹H NMR spectroscopy. The identification of HAP powders composition before and after a treatment with hydrochloride acid was confirmed using XRD and IR spectroscopy. The crystallite size in powders is decreased (vs the specific surface area is increases) interacting with hydrochloride acid. The hydrochloride acid leads to minimum crystallites size in HAP / HA composite. This effect could be cause by formation of stable clusters of absorbed water solving the acid badly. This could be used to create composites of biocompatible, stable in an acidic medium.

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