Chemistry, Physics and Technology of Surface, 2010, 1 (4), 457-464.

Interaction of Red Blood Cells with Fumed SiO2, Al2O3/SiO2 and TiO2/SiO2 by Light Scattering Measurements



I. I. Gerashchenko, V. M. Gun'ko, V. I. Zarko, B. I. Gerashchenko, L. S. Andriyko, V. F. Gorchev

Abstract


The interaction of human red blood cells (RBCs) with fumed silica and fumed X/SiO2 (X = Al2O3, TiO2) at different concentrations of X oxide was studied by flow cytometry and photon correlation spectroscopy. The light scattering of RBCs affected by oxides in conjunction with the hemolysis degree showed that mixed oxides (X/SiO2), in general, had less membranotoxic effect than pure silica. The interaction of RBCs with fumed silica and other mixed oxides is a convenient model to examine membranotoxicity and biocompatibility of disperse materials. Flow cytometry and photon correlation spectroscopy are informative methods to study the mechanism of hemolysis induced by solid micro- or nanoparticles.

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Copyright (©) 2010 I. I. Gerashchenko, V. M. Gun'ko, V. I. Zarko, B. I. Gerashchenko, L. S. Andriyko, V. F. Gorchev

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